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Redrobe JP, Elster L, Frederiksen K, Bundgaard C, de Jong IE, Smith GP, et al

When relief of pain from treatment with GnRH agonist supports continued therapy, the addition of add-back therapy reduces or eliminates GnRH agonist-induced bone mineral loss and provides symptomatic relief without reducing the efficacy of pain relief

Moreover, dendritic spines that receive most excitatory synaptic inputs have been shown to contain no mitochondria (Kasthuri et al., 2015), despite being sites of intense energy utilization

Wendland M