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Additionally, in pupil dilation assays, a common point of action of L-NAME/L-arginine was noted (in miosis, both L-NAME and L-arginine antagonized the response to the other)

Knockdown of one factor in the pathway may improve but not fully disrupt the muco-inflammatory cycle due to the multifactorial and overlapping regulators of mucin secretion

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5 Once steady state is reached, the washout period for AJOVY is similar for monthly and quarterly dosing (~5-6 half-lives) 6 Washout period defined as time until plasma concentrations of AJOVY are below a clinically relevant concentration and thus considered eliminated