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Increasing Breast Cancer Incidence in China: The Numbers Add Up

Liu B, Luo W, Zhang Y, Li H, Zhu N, Huang D, et al

Iron deficiency anemia tends to produce pallor rather than dark spots, but B12 deficiency has been associated with diffuse lip hyperpigmentation in clinical literature

While the results have been mixed, the potential for melanocortin-based therapies to address a variety of dermatological and systemic conditions remains an area of active investigation