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Zinc is also involved in the production of metallothionein, and a deficiency in zinc can lead to decreased metallothionein production, further exacerbating copper overload

A report from Japan indicated that homologous expression of codon-optimized MT-ND3 in patients with MT-ND3 mutations can increase ATP production and improve mitochondrial function, showing promise as a potential new treatment strategy (71)

In terms of enzyme induction, natural (R)-SFN has been shown to be a more potent inducer of carcinogen-detoxifying enzyme systems in rat liver and lung compared to the (S)-isomer [130]