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For bacterial diversity analysis, V3-V4 variable regions of 16S rRNA genes were amplified with universal primers 343F (5-TACGGRAGGCAGCAG-3) and 798R (5-AGGGTATCTAATCCT-3) ( 2.7 SCFA concentration analysis The levels of SCFAs in the sera of mice were measured with GCMS analysis

[0232] Embodiment 225: The method according to any one of embodiments 213- 224, wherein said cancer comprises cells of a cancer selected from the group consisting of mesothelioma, testicular cancer, endometrial cancer, and ovarian, pancreatic, and non small cell lung cancers that express ALPP and/or ALPPL2

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Antagonists or neutralizing antibodies against IL-1, TNF-, and IL-6, such as IL-1Ra and anti-TNF-, have been extensively studied in OA