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Conjugation with the ligands that specifically interact with the targeted receptors, those on the BBB and neurons (e.g., folate, lactoferrin, transferrin, insulin, and LDL receptors), enhances the BBB penetration, neuron-targeting efficiency (Guo et al., 2020), and also increases drug bioavailability in the CNS (Gopalan et al., 2020

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Laser treatments such as laser toning and pigmentation removal typically cost between 5,000 to 15,000 per session, depending on the technology used and the area being treated