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According to current AD hypotheses, tau becomes abnormally phosphorylated, dissociates from microtubules, and aggregates into NFTs (193)
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CastilloRCarrascoRlvarezPRuizMLuchsingerVZuninoEet al

This Phase III backup results in a buildup of oxidized waste-products known as free-radicals that damage cells, cause inflammation and other disease processes
