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CLA-DY can also catalyze the reduction of 11( E )-10-oxo-OME into 11( E )-10-HOME, which is dehydrated by CLA-HY into two conjugated-LA compounds 9( Z ),11( Z )-ODE and 9( E ),11( Z )-ODE (Scheme 22)

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Under homeostatic conditions, two molecules of Keap1 are bound to the Neh2 domain of Nrf2 at the ETGE and DLG motifs ( via their Kelch-repeat domain) (Fig

Since 2017, the National Institute for Health and Care Excellence (NICE) has recommended that all people with colorectal cancer are tested for Lynch syndrome using Immunohistochemistry (IHC) or Microsatellite Instability (MSI) testing (DG27)