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Description
In addition to the leak and pore pathways, there is also the unrestricted (or apoptotic) pathway, where severe damage to the gut mucosa results in death of epithelial cells and permits unrestricted paracellular transport of large molecules and bacteria

293 WangS.TsunZ
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This process activates oncogenes or inhibits tumor suppressor genes, thereby promoting tumor formation and development

Diagnosis Upper gastrointestinal endoscopy, a camera inserted on a long tube down to the stomach, is necessary for a conclusive diagnosis of peptic ulcer
