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The compelling safety profile of these polyphenols, especially when compared to non-steroidal anti-inflammatory drugs (NSAIDs), implies their prime utility as long-term adjunctive therapies or for individuals intolerant to conventional pharmacotherapy

524 In the advanced stages of atherosclerotic disease, macrophages destroy the collagen of the fibrous cap and induce smooth muscle cell death by secreting multiple types of inflammatory factors and matrix metalloproteinases (MMPs), thus exacerbating plaque instability

We then identify their frequency in toxic and non-toxic classes, and select ten with the largest frequency difference between classes

Adiponectin enhances insulin sensitivity and has anti-inflammatory actions (Khoramipour et al., 2021)