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Epigenetic regulation of T cell exhaustion

Based on the previous studies, we concluded that many important molecules related to genes in neural signal transduction play an important role in circadian rhythm regulation

Emerging regulated cell death mechanisms, such as ferroptosis and the complex interplay between autophagy and apoptosis, are not yet fully elucidated, restricting the development of targeted therapies in this field [7]

Such widespread protective effects have created strong incentives to develop new potent enhancers of NRF2 activity for the prevention and treatment of many diseases (several of which are presently incurable) in which both inflammatory and oxidative stress have a key pathogenic role