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10.1016/j.tins.2004.05.013 Trends Neurosci

They manifest no abnormalities in adulthood, live 15% longer than wt animals and are resistant to a high glucose diet (Figs 6a and 7a)

Finally, we found the defects in neurite initiation seen in KD neurons were rescued by the treatment of KD neurons with JNK inhibitor, SP600125 (Figure 7)

It acts as a signaling molecule to upregulate the gene expression and activity of the body's native antioxidant enzymes
