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Tirzepatide is given subcutaneously once a week and was examined in four worldwide phase III randomized, placebo-controlled clinical trials as part of the SURMOUNT Program, which also includes lifestyle modification

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Research indicates that the dopamine (DA) surge from amphetamine abuse can cause oxidative stress, neuronal death, and morphological changes in the hippocampus, particularly reducing neuron density in the CA1 region and Zn concentration 25,26,27