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Theranostics 7 , 18751889 (2017)

As pointed out by the legendary immunologist Andrea Ablasser, such a universal sensing mechanism violates one of the most fundamental rules of the classical pattern recognition dogma, which is based on pathogen-specific structural patterns instructing self- versus nonself discrimination ( Therefore, the aim of the present work is to motivate a wider application of the lessons learned from the experiences with COVID-19 and the new mRNA vaccines to combat future non-COVID-19 diseases, providing preliminary and associational evidence for the hypothesis: "Self-DNA-driven inflammation is one of the factors that contribute to severe COVID-19 and to certain adverse events subsequent to COVID-19 mRNA vaccination