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The core principle is chemical: copper is a redox-active metal, and pairing it carelessly with strong acids or potent oxidizers/reducers in the same layer can destabilize one or both ingredients and increase irritation
Br J Dermatol (2001) 144(1):5565
As with any supplement, check with a healthcare professional if you're pregnant, on medication, or managing a health condition
They include opioids, inhalers, decongestants, antidepressants, blood pressure drugs and benzodiazepines, like Xanax, used to treat anxiety
