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The data indicated VTE risks of 1.9 times (95% CI, 1.3-2.3) for users of oral estrogen compared to nonusers of estrogen and 1.0 times (95% CI, 0.9-1.1) for users of transdermal estrogen

For the pulmonary fibrosis evaluation, the fibrosis index calculated based on MT staining, collagen deposition and active TGF-1 expression detected by ELISA, and the expression of TGF-1, -smooth muscle actin (SMA), fibronectin, MMP-9, and TIMP-1 by western blotting

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Such effects could offer new hope for preventing or slowing neurodegenerative diseases such as Alzheimers and Parkinsons disease (1)