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Compared to a natural history cohort comprising patients pooled from 11 natural history studies, there was a statistically and clinically relevant difference in BCVA of 0.33 (+ 16.5 ETDRS) in favour of treated eyes at 48 months after the onset of vision loss ( p A mutation using the technique of allotopic expression, GS010 remains an experimental therapy that has not yet been evaluated by the US Food and Drug Administration (FDA) and the European Medicine Agency (EMA)

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[DOI] [PubMed] [Google Scholar] Kurz D, Ciulla TA

Dihydroorotate dehydrogenase (DHODH) is an enzyme localized in the inner mitochondrial membrane which catalyzes the fourth step of de novo pyrimidine synthesis
