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Obesity represents itself as a challenge for hypothalamus-pituitary-thyroid axis since it has been hypothesized that hyperleptinemia, that often characterizes these patients, may increase the expression of TRH gene and thus TSH secretion [194]

The rats were randomly divided into 4 groups (each group of 20 rats): group A1 (normal control group under normoxia), group A2 (normal control group under normoxia, received low-dose l-carnitine at 50 mg/kg), group A3 (normal control group under normoxia, received high-dose l-carnitine at 100 mg/kg), group B (plateau model control group, received injecting normal saline), group C (low-dose l-carnitine intervention altitude model group, received 50 mg/kg l-carnitine) and group D (high-dose l-carnitine intervention altitude model group, received 100 mg/kg l-carnitine)

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