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Description
microbiology and molecular biology reviews 62:725774

Could an impairment in local translation of mRNAs in glia be contributing to pathogenesis in ALS

We introduced the corresponding mutations in PIF4, creating the RRQQ variant, and also generated a basic-cluster mutant (mB)

This damage includes mtDNA mutations and copy number fluctuations, disruption of mitochondrial protein homeostasis, and respiratory chain complex dysfunction
