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The articles were selected based on their relevance, scientific rigor, and contribution to the understanding of the proposed vicious cycle. We prioritized studies that provided mechanistic insights or direct evidence within endometriosis or highly relevant biological systems

Vagotomy in animal studies is said to disrupt the transfer of -synuclein derived from the gut to the CNS, but human observational evidence is inconsistent, with some studies indicating no change in PD incidence and others suggesting a reduced risk following truncal vagotomy (Elfil et al., 2020)

Ingredients Amount Per Serving %DV Vitamin B6 (as pyridoxal 5-phosphate) 5 mg 250% Folate (as Quatrefolic (6S)-5-methyltetrahydrofolic acid, glucosamine salt) 100 mcg 25% Vitamin B12 (as MecobalActive methylcobalamin) 100 mcg 1667% Acetyl-L-Carnitine (as acetyl-L-carnitine HCl) 250 mg ** N-Acetyl-L-Cysteine 100 mg ** Ginkgo Extract (Ginkgo biloba)(leaf)(24% ginkgoflavonglycosides and 6% terpone lactones) 60 mg ** Bacopa Extract (Bacopa monniera)(leaf)(20% bacosides) 50 mg ** Phosphatidylserine (SharpPS GREEN) 15 mg ** Vinpocetine 5 mg ** trans-Resveratrol (from Polygonum cuspidatum root extract) 1 mg ** Huperzine A (from Huperzia serrata)(aerial parts) 100 mcg **

SAH is a potent competitive inhibitor of methylation reactions and prompt removal of adenosine and Hcy is required to prevent accumulation of SAH