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Notably, these macrocyclic peptides exhibit noncompetitive behavior with either SAM or NAM, suggesting that they may function as allosteric inhibitors targeting NNMT (Van Haren et al., 2021)

Regulation of enzymes with identical subunits on the example of transketolase

Volpe CMO, Villar-Delfino PH, Dos Anjos PMF, Nogueira-Machado JA
Mutant mice were born with red, shiny skin that rapidly dried and died, lacking typical ichthyosiform lesions (Moran et al., 2007)
