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When glutamate was injected into the ganglia innervating the temporalis or masseter muscle, there was a significant increase in nociception (decrease in afferent mechanical thresholds) that was attenuated by NMDAR antagonists (2R)-amino-5-phosphonovaleric acid, AP-V) or worsened by EAAT blockers (3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-aspartic acid, TFB- TBOA) [267]

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10.1016/j.phymed.2024.155554 Summary Keywords Chinese medicine, natural metabolites, CVDs, flavonoids, alkaloids, saponins Citation Liu X, Zhang W, Miao X and Hu Y (2025) Natural metabolites used in traditional Chinese medicine for cardiovascular diseases: pharmacological mechanisms, evidence, and future directions