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Description
GPX4 enzymatic activity strictly depends on a continuous and sufficient supply of intracellular GSH
In a mouse model of hepatocellular carcinoma, regulatory T cells (Tregs) with high IGF-1R expression presented increased PI3K/AKT/mTOR signaling and were able to produce more ATP, lactate and ROS, which contribute to enhanced immunosuppressive effects (72)
Moreover, in IGF-1R null tumors, IGF-2 increases -catenin levels, a key mediator of EMT
However, intranasal delivery of curcumin has shown to enhance its brain uptake efficiency in a rodent model of oxidative damage in cortical neurons[141]
