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Two published studies examining SCE frequency in epileptic patients treated with valproate versus untreated epileptic patients, provided contradictory results

Both central and peripheral injections of CRF inhibit gastric and proximal small bowel motor activity and induce vomiting in experimental animal and humans (43)

The experimental design included 35 juvenile male Western albino rats, distributed into five groups of seven animals each: untreated controls, PPA alone, and PPA followed by treatment with omega-3, vitamin B12, or their combination