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The nucleophilic attack by the hydroxyl group (OH) of glucose on the terminal () phosphorus atom of ATP is facilitated by Mg 2+ , which stabilizes the negative charges on the phosphoryl groups of the nucleotide triphosphate

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( F ) Heatmap of RNA sequencing of non-malignant (NHA Donor #1), AGAT low (MGG152, BT260), and AGAT high (all other) GSC cell lines comparing relative abundance of GATM mRNA splice isoforms ( n =2 per line)

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