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Late onset acute GVHD can also occur particularly if DLIs are used to improve chimerism

Data available from Asian joint registries suggest that patients often undergo TKA at later stages of stiffness and degeneration 141 , implying a possible delay in opting for surgery, although causality is multifactorial

Prolonged higher OS leads to various life-threatening pathological conditions such as aging, heart diseases, diabetes, autoimmune diseases, cancer, neurological disorders, etc

In addition to these metabolic and nutritional pathways, gut microbiota dysbiosis also influences neuroendocrine regulatory mechanisms through modulation of neurotransmitter synthesis