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The catabolism of the catecholamines, epinephrine, norepinephrine, and dopamine, involves the SAM-dependent enzyme catechol O -methyltransferase (encoded by the COMT gene)

These studies have been supported through skin biopsies, revealing a decrease in the number of epidermal fibers, and clinically in subjects presenting the pathology, obtaining higher scores in questionnaires related to neuropathic pain and the presence of alterations in perception thresholds for heat, cold, and pain [12]

Kolanu ND, Awan NA, Butt AI, Reza T, Almadhoun MKIKH, Janoowala T, Bokhari SFH, Zain Z, Sharif T, Chauhan L, Choudhari J

Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8