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No single finding or test result will confirm the presence or absence of this disease, but rather, accurate diagnosis lies with comparison against a pre-established set of criteria, as defined by the American Rheumatism Association
Cell 24 , 643652 (2006)

Furthermore, the helical arrangement of ventricular myocardial fibers creates sufficient and coordinated forces to pump blood within the body

This has been shown to result in decreased production of pro-inflammatory cytokines such as Tumor Necrosis Factor alpha (TNF-), interleukin 6 (IL-6), interleukin 8 (IL-8), and interferon gamma (IFN-), and inflammation markers such as cyclooxygenase 2 (COX2) 26,45