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Autophagy has been proposed as an inhibitor of tumor initiation by removing damaged proteins and organelles, protecting cells from reactive oxygen species (ROS), necrosis, inflammation, genomic instability, and metabolic alterations [107]

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PaengSHJungWKParkWSLeeDSKimGYChoiYHet alCaffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1alpha signaling pathways in human retinal pigment epithelial cells under hypoxic conditions

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