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GOT2 catalyzes the conversion of oxaloacetate to aspartate in the mitochondria and has been shown to be an important regulator of cancer metabolism (13)

Res.) to match the weight loss of GLP-1MK-801 ( n = 8 mice and n = 4 cages) or vehicle (isotonic saline, n = 8 mice and n = 3-4 cages) for 14 days

The main disadvantages of CUR are the poor oral bioavailability in terms of low intestinal absorption rate, rapid metabolism, and excretion from the body [62] due to the hydrophobic (low solubility in water) and lipophilic (highly soluble in lipid) nature of CUR [63]

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