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Design, synthesis and characterization of novel co-polymers decorated with peptides for the selective nanoparticle transport across the cerebral endothelium

RCT evidence: A: Robust replicated results from at least 2 large long-term double-blind RCT, ideally with confirmation from a systematic review or meta-analysis B: Supporting evidence from the primary outcome of at least one large long-term double-blind RCT C: A lack of supporting evidence from the primary outcome of a large long-term double-blind RCT but promising results from either small pilot RCTs or from post-hoc and planned secondary analyses

In particular, activated PLC hydrolyzes the membrane lipid phosphatidylinositol-4,5 bisphosphate (PIP2), to produce second messengers, i.e., inositol triphosphate (IP3) and diacylglycerol (DG)

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