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Competition Flow Team registration December 15, 2025 Background materials on data format will be provided Data release December 19, 2025 Teams will receive a labeled dataset with known incumbent user activity Algorithm submission and evaluation February 27, 2026 Teams will submit their implemented algorithms, including low-level design documents Algorithms will be tested against several unreleased datasets to assess their performance Submissions will be scored based on the specified evaluation metrics Results and recognition Spring 2026 SpectrumX Center Meeting (June 1-2 2026) Evaluation Metrics Groups will be evaluated based on four criteria

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Leukemia 29:20392049 Richardson P, Perrot A, San-Miguel J, Beksac M, Spicka I, Leleu X et al (2021) Updates from ICARIA-MM, a phase 3 study of isatuximab (Isa) plus pomalidomide and low-dose dexamethasone (Pd) versus Pd in relapsed and refractory multiple myeloma (RRMM)