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Yu H, Kim PM, Sprecher E, Trifonov V and Gerstein M (2007) The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics
Importantly, these methods also allow for the integration of OMICs data such as transcriptomics, proteomics, and metabolomics to reconstruct metabolic models that more accurately reflect the metabolic state of cells in a given condition, so-called context-specific metabolic models 18
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