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Description
The incidence of fatigue, cognitive impairment, insomnia, joint pain and numbness in chronic LD is increased in some studies, while others report no difference from controls
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This circumstance has made it difficult to translate mouse results to the clinic
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the gold standard for quantifying dihexa in plasma, with a lower limit of quantification typically around 15 ng/mL depending on sample preparation and ionization efficiency
