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All experimental procedures were approved by the Washington State University Animal Care and Use Committee

Graphical abstract Similar content being viewed by others The importance of autophagy in cell homeostasis Autophagy and the ubiquitin proteasome system (UPS) are two major intracellular degradative mechanisms that mediate the catabolism of proteins and organelles

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In addition, GSH depletion induced SIPS, as evidenced by increased percentage of the senescence-associated -galactosidase-positive cells, increased senescence-associated heterochromatin foci (SAHF), as well as cell cycle arrest at the G1 phase