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It has been shown that fisetin reduced senescence in a cell type-specific manner: in white adipose tissue (WAT), it reduced mesenchymal stem/progenitor, immune, and endothelial cells, while senescent dendritic cells and macrophages were not changed

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People who should not take lipotropic injections include those who are pregnant or breastfeeding, individuals with a known allergy to any of the injection ingredients (particularly sulfa-related sensitivities due to methionine), people with severe liver or kidney disease, and those taking certain medications that may interact with the supplement ingredients