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Directly and indirectly through multiple reactions which include enzymatic reactions, glutathione is oxidized to form GSSG, which is then reduced to GSH, its "active form" by yet another enzymatic reaction (3)

Diabetes-driven ferroptosis reflects a switch in cellular energy sources, mitochondrial dysfunction, and iron overload, leading to reduced insulin secretion

doi: 10.1126/science.505013 157 JaureguiC.Blanco-LuquinI.MacasM.RoldanM.CaballeroC.PagolaI.et al

Neuro-oncology 23, iii1iii105
