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Within the first 2 d of withdrawal, BZDs reduce the incidence of seizures by up to 84% and prevent the development of DT.74 The current literature does not suggest one BZD to be more efficacious than another, although differences in pharmacokinetic properties can guide selection.71, 73, 74, 75 The following recommendations include agents 75 with rapid onset to control agitation symptoms with long action to avoid breakthrough symptoms with less dependence on hepatic metabolism to lower the risk of over sedation Diazepam fulfills the first two aspects and represents the primary choice

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The main reported result was a large difference in mortality among patients with ALF compared to acute liver injury, both defined according to the United States Acute Liver Failure Study Group criteria