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& Bridge, W

The restoration of mTOR signaling with Fer1 rescue treatment in the context of RSL3 effects, and the genetic knockdown of GPX4, reaffirm our in vitro findings that RSL3-mediated induction of ferroptosis, mTOR pathway suppression, DNA damage and failure of DNA repair, and autophagy are GPX4-dependent processes in thyroid cancer cells

doi: 10.1007/s11894-010-0120-5

Its mechanisms involve direct scavenging of free radicals, activation of the Nrf2 pathway to enhance cellular antioxidant defenses, and upregulation of SIRT3 to improve mitochondrial function and biogenesis [192]
