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Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]
Khan, S
doi: 10.1053/j.gastro.2018.12.019 87 IbarraA.Latreille-BarbierM.DonazzoloY.PelletierX.OuwehandA
doi: 10.1016/j.addr.2025.115572
