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Step 1: Exposure to UV radiation generates Reactive Oxygen Species (ROS) [3] Step 2: High levels of ROS induce oxidative stress, which leads to Tyrosinase activation, the enzyme responsible for melanin synthesis

Acknowledgements This work was supported by grants from the Swedish Cancer Fund (Cancerfonden), the Swedish Research Council (VR), Radiumhemmets Forskningsfonder and Karolinska Institutet

Idiopathic VKDB is defined by the fact that no cause other than breast feeding can be determined

References 1 US Department of Health and Human ServicesCenters for Disease Control and Prevention, and National Cancer InstituteUS Cancer Statistics Working Group