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Additionally, they often require tedious sample preparation

10.1016/j.bbrc.2007.08.142 121 ReniereM

Zinc has also shown potent effect in attenuation of pro-inflammatory cytokines including Interleukin-6, Tumour Necrosis Factor (TNF-), and C-Reactive protein and stimulation of the molecular signalling pathway leading to expression of the A20 protein (Marreiro et al., 2017)

In fact, they may even restrict its efficacy (Wang et al., 2021)
