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CONCLUSION This review aimed to elucidate the principal mechanisms involved in the neuropsychiatric manifestations of COVID-19, which involve glutamate dysregulation, Xct, Nf-B, mGluR2, and mGluR3, astrocyte and glial damage and neurotoxicity highlighted as central factors [15], exploring the potential of NAC and ALC as promising therapeutic agents in neuropsychiatric conditions COVID-19-related, including those associated with PCS

Shibata, T., et al.,Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

Byun HM, Colicino E, Trevisi L, Fan T, Christiani DC, Baccarelli AA

The resulting glutamine is subsequently transported to neurons, where it is converted back into glutamate by glutaminase, providing a continuous supply of this key excitatory neurotransmitter 35,71
