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Here and in previous reports, we have identified that ELAM treatment in both old male and female mice improves muscle mitochondrial function, treadmill endurance, sub-maximal muscle force production, and diastolic heart function [11,12,13,14]

Some studies suggest that they do not, and other studies suggest that they may possibly worsen symptoms after 3-4 months.[104] Therefore, using probiotics during times of worsening symptoms, while incorporating other modalities, may be the best approach

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" So maybe downregulation of 5HT 1A by NSI-189 is causing hyperalgesia