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Similarly, subcutaneous administration of progesterone prevented mechanical and thermal allodynia in male rats following SCI rats, and decreased levels of the pro-inflammatory cytokines IL-1, IL-6, and TNF in the spinal cord dorsal horn, supporting the notion that progesterone has a capability of suppressing reactive gliosis following CNS injury [373]

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Therefore, to mitigate the total level of AFs in spices, medicinal herbs, and other popular plant-based food additives, local and international herbal markets, however, should be constantly monitored for detection of AFs metabolites (167, 168)

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