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To surmount the adverse effects of long blood sample transport times from the zoo to the laboratory on sample quality, we established a vaccine-specific interferon- (IFNG) release-based, point-of-care whole blood stimulation assay that can be carried out and preserved at the trial site for subsequent gene expression analysis, starting with measuring IFNG as a correlate of T cell activation

Figure 2 depicts the varied phenotypes of microglia, namely M1 and M2, in response to different neurodegenerative conditions

The majority of agents targeting these signaling axis remain in preclinical research and some in phase I study for dosage and safety evaluation

Endothelial cell senescence in human atherosclerosis: Role of telomeres in endothelial dysfunction