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These include the high temperature and/or high pressure of the enema fluid, the chemical residues (e.g., cleanser or disinfectant) inside the catheter, or the thermal injury caused by the catheter

1, 2, and 3 in the original) Evidence-Base Disclosure The published evidence base for Epithalon consists predominantly of preclinical research animal models (often rats or mice) and in vitro cell-culture experiments

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Here, we combined the dCas9-VPR CRISPR activation (CRISPRa) system with gRNA-V, the truncated Bid (tBid)-based suicide gene strategy and CD3-retargeted adenovirus (Ad) delivery vectors, in an all-in-one targeted shock-and-kill gene therapy approach to achieve specific elimination of latently HIV-1 infected cells