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Infection represents another major obstacle

Glia within the NVU are crucial components that ensheathe the endothelium forming a socalled secondary barrier, and nutrients required for CNS function are delivered from the blood vessels to neurons mainly via glia cells (reviewed by (Hurley et al., 2015)), while waste compounds are passed via glial cells to microglia or back into the bloodstream (reviewed by (Marina et al., 2018))

doi:10.1186/s12978-019-0769-7

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