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A recent systematic review and meta-analysis of 21 randomized, placebo-controlled trials examining the effect of B-vitamin supplementation found the supplementation decreased homocysteine concentrations and improved measures global cognitive function but had no effect on individual measures of executive function, information processing speed, or episodic memory (89)

This therapy not only improves communication and promotes social interaction, but also reduces the use of antipsychotic drugs, prevents wandering, and improves quality of life

We like methylcobalamin because it reduces homocysteine levels and generates a crucial methyl donor called S-adenosyl methionine (SAMe)

2 Likes Kelman January 31, 2026, 11:50pm #33 Beth: Just sharing that after using DSIP after almost a month, I see zero difference to my deep sleep (according to OURA) Most of my doses were 250mcg Absolutely ZERO effect for me either