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John's wort creates the biggest risk, especially in "natural" energy products

Cryopreservation induces excessive generation of ROS and causes sperm cell damage with extreme sensitivity to ROS owing to limited cytoplasm, low antioxidant capacity, and higher level of polyunsaturated fatty acids (PUFA) in plasma membrane of sperm cells

The enhanced increase in ME/CFS cases (Figure 7) most likely reflects some compensation for a lack of alternative energy sources
